Glutamine

substance Amino acids

Proresilient

Glutamine is a conditionally nonessential amino acid that can be synthesized endogenously in sufficient amounts. It performs multiple biological functions, including regulation of nitrogen metabolism, participation in nucleic acid synthesis, neurotransmission, conversion to γ-aminobutyric acid (GABA), and involvement in the synthesis of hormonal and neurotransmitter mediators, redox enzymes, and the modulation of myocyte membrane permeability to potassium ions. Glutamine also contributes to the enhancement of nonspecific immune responses.

Сhronoblocking properties

Glutamine is widely used as a component of dietary supplements aimed at recovery following intensive physical exercise. Its physiological effects are largely mediated through its role in ammoniagenesis, which supports acid–base balance during increased metabolic demand. This mechanism contributes to improved tolerance to physical нагрузкам and supports recovery after high-intensity training. By enhancing exercise tolerance and supporting immune and metabolic functions, glutamine positively influences the physical component of age-related resilience. Although there is no evidence of a direct effect on lifespan extension, these properties allow glutamine to be classified as a proresilient substance (Brosnan, J. T., 2004).