Substances
About Database
Substances
About Database
Coenzyme Q10 is involved in oxidative phosphorylation and serves as an electron carrier within the mitochondrial respiratory chain, playing a critical role in mitochondrial function. It is a potent antioxidant that regenerates the antioxidant capacity of vitamin E and is essential for tissues with high energy demand, particularly the brain.
Currently, there is no conclusive evidence supporting the use of coenzyme Q10 for the prevention of cardiovascular diseases or other proxy diseases of aging. However, coenzyme Q10 may be used as a proresilient agent to enhance adaptive capacity in patients with atherosclerotic disease and its clinical manifestations, as well as in systemic metabolic disorders at both early stages (such as left ventricular diastolic dysfunction) and advanced stages, including chronic heart failure. Beneficial effects have also been described in disorders of cardiac rhythm and conduction (Madmani, M. E. et al., 2014). Several studies have reported the potential role of coenzyme Q10 as an adjunct therapy in arterial hypertension, contributing to improved achievement of target blood pressure levels (Rosenfeldt, F. L. et al., 2007). As an adaptogenic and proresilient compound, coenzyme Q10 may also be used to support statin therapy. In some patients, statins are associated with reduced mitochondrial function in skeletal muscle, leading to the development of statin-associated myopathy. Coenzyme Q10 supplementation may help prevent these effects and, through this mechanism, improve patients’ functional capacity (Päivä, H. et al., 2005).
